高龄夫妻做三代试管婴儿筛查后宝宝出生还会基因突变吗？
Most babies born after a three-generation IVF screening are free of genetic mutations, unless they are newly developed. Three-generation IVF allows for chromosomal and genetic screening to select embryos for transfer that do not have a clear causative genetic disorder. If there is a clear causative gene indication, such as a family or parents with a clear causative gene, such as geographic anemia, color blindness, or other single-gene disorders, three-generation IVF can be used to block genetically inherited diseases.
Genetic mutation is a sudden, heritable variation in the DNA molecules of the genome. The PGS technology in three-generation IVF will screen the embryos genetically before implantation, and the embryos will be tested for chromosome number and structure abnormalities using PGS technology, which mainly detects the 23 pairs of chromosome structure and number of the embryos, and analyzes the embryos for any abnormalities of the genetic material through comparison. Therefore, after screening the embryos with three-generation IVF PGS technology, there will be no more genetic mutations in the embryos.
As the three-generation IVF PGS screening technology is not able to 100% guarantee that embryos with genetic mutations can be screened out, if there are extremely hidden disease genes inside the parents' genes, then there may be cases that are not screened out in the preliminary screening, resulting in babies inheriting undesirable genes and giving birth to deformed babies after birth. Therefore, patients who are pregnant through three-generation IVF must undergo regular obstetrical examination after pregnancy, and if any problem is found with the embryo, they should ask the doctor for treatment or improvement in time, and terminate the pregnancy if necessary, to avoid causing harm to themselves.
