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With the continuous progress of technology, “IVF” has gone through the iterative development of the first, second and third generations, and solved the problem of female infertility, male infertility to the level of eugenics. Among them, the third-generation IVF technology is expected to become the hottest track in the field of assisted reproduction under the favorable three-child policy. Third-generation IVF (PGT-A) technology can make up for the shortcomings of first- and second-generation IVF technology, optimize embryos from the genetic level, and effectively improve the success rate of IVF.

The third generation IVF technique (PGT), also known as pre-implantation genetic testing (PGT), refers to the genetic testing and detection of chromosome number and structural abnormalities before implantation into the mother's uterus after the sperm and egg unite to form a fertilized egg and develop into an embryo in vitro. This method can directly screen out problematic embryos and select embryos with normal genetic material for implantation into the uterus, thus increasing the pregnancy rate, decreasing the miscarriage rate, and preventing the birth of children with single-gene disorders and chromosomal abnormalities.

Which groups of people are suitable for PGT III IVF?

Chromosomal abnormalities: including reciprocal translocation, Roche translocation, inversion, complex translocation, pathogenic microdeletions or microduplications;

2、Single gene disease: such as thalassemia, hemophilia, polycystic kidney, hereditary deafness, phenylketonuria and so on;

3, PGT-A: with the following factors: advanced age, 38 years and above; unexplained repeated spontaneous abortions; unexplained repeated implantation failures, etc. Embryos without chromosomal abnormalities can be transferred to improve the clinical pregnancy rate and reduce the miscarriage rate and birth defects.

Is it necessary to do genetic testing before third generation IVF?

“Third Generation IVF Technology”, the most important primary preventive measure for screening and diagnosis of embryos, can cut off the transmission of defective genes from the source of life. Third generation IVF performs genetic testing on embryos before transfer to screen healthy embryos for implantation into the mother. IVF 3rd generation genetic sequencing takes one month.

The significance of doing genetic test screening

1、Removal of genetically abnormal embryos

Pre-implantation genetic diagnosis (PGD), also known as preconception diagnosis, is a genetic diagnosis of embryos before they are implanted in the uterus. Eliminating genetically abnormal embryos and implanting only genetically normal embryos into the uterus is a positive form of eugenics. Compared with the prenatal diagnosis technique of taking amniotic fluid in the middle of pregnancy, prenatal diagnosis avoids the disadvantage of selective abortion after abnormal fetus is found in prenatal diagnosis.

2、Screening carriers of various genetic diseases

Carriers and patients of various genetic diseases, including: single-gene genetic diseases, chromosomal diseases, familial tumors; elderly people (women over 38 years old) who need to have children; couples with habitual miscarriage and multiple implantation failures; couples suffering from primary infertility and poor reproductive history.

3、Check for chromosomal defects

Doctors can detect defects in the chromosomes that carry the human genetic code in a woman's eggs. An error in the number of chromosomes in an egg cell can lead to miscarriage of the embryo or serious infant disorders such as Down syndrome. As many as half of young women's eggs and 75% of women over 39 have chromosomal abnormalities.

4. Eliminating chromosomal abnormalities in eggs

For women of age 35 and older, they are called senior citizens. Pregnancy in older women is risky. This is because of the high rate of chromosomal abnormalities in the eggs in the body, which can lead to infertility. IVF is designed to solve this problem, but before the implementation of IVF technology, it is necessary to carry out female chromosome examination before the procedure.

5. Screening embryos for chromosomal abnormalities

Doctors can analyze the chromosomes of the embryos before they are implanted in the uterus, and only transfer chromosomally normal embryos, which can effectively improve the success rate of IVF, reduce the rate of miscarriage, help families with high genetic risk to give birth to healthy babies, avoid the birth of genetically abnormal babies, and reduce birth defects in the population.